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我科学家发现生物遗传突变普遍机制  发帖心情 Post By:2008/8/12 15:56:21

      在丰富多彩的生命世界,究竟什么原因造就诱人的生命多样性?南京大学教授经多年潜心研究大胆提出“Indel诱变假说”,用新发现的“遗传突变的普遍机制”破解了生物学上的诸多悬念。7月20日,最新出版的《自然》杂志刊登了南京大学自主完成的这一研究成果。  

  在《自然》发表的《真核生物中插入/缺失增加其周围序列的突变率》这篇论文,是南京大学生命科学学院教授田大成、陈建群等自主完成并数易其稿的智慧结晶。  

  2005年起,他们通过生物信息学技术对人、黑猩猩、恒河猴、小鼠、果蝇、水稻和酿酒酵母等不同类别生物的基因组序列进行了比对分析。研究后发现,DNA的插入/缺失(Indel)会引起其周围一系列的变异。在此基础上,他们提出了“Indel诱导自发突变机制假说”,从源头上成功回答了“遗传变异究竟是如何形成的”这一生命科学面临的基本问题。该假说可用不同物种的基因组作参照系加以检验,并得到多种检验结果的支持。  
本报讯(记者 张晔 通讯员  罗静)  在丰富多彩的生命世界,究竟什么原因造就诱人的生命多样性?南京大学教授经多年潜心研究大胆提出“Indel诱变假说”,用新发现的“遗传突变的普遍机制”破解了生物学上的诸多悬念。7月20日,最新出版的《自然》杂志刊登了南京大学自主完成的这一研究成果。  

  

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